B6.B6CB-Disc1<tm1Kozo> B6.B6CB-Disc1<tm1Kozo> Cre/loxP system Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Hum. Mol. Genet., 20, 4666-4683 (2011).<br>(1) 分与希望者は事前に 貝淵　弘三 (kaibuchi@med.nagoya-u.ac.jp) に連絡をとり、分与に関して許可を得ること。(2) 当該マウスを用いる論文発表に際してはAccession No. CDB0583K、そのWEB サイトhttp://www2.clst.riken.jp/arg/mutant%20mice%20list.htmlとともに当該マウスを記載すること。(3) 当該マウスを用いる論文発表に際しては、その由来として第一報論文（未定）を引用すること。（4）発表論文を寄託者（mutant.bdr@riken.jp）に連絡すること。 true RIKEN CDB RIKEN CDB C (3-6 months) Disc1 knockout mice. Most of exon 2 and all of exon 3 of Disc1 gene were replaced with a loxP/PGK-Neo-pA/loxP cassette. Homozygous mutant mice are viable and fertile. Disc1遺伝子のノックアウトマウス。Disc1遺伝子のエクソン2と3がloxP/PGK-Neo-pA/loxPカセットで置換されている。Disc1遺伝子は、統合失調症脆弱性因子の一つであり、ヒトの家系において、染色体相互転座によるDISC1タンパク質の発現の低下が、統合失調症を含めた精神疾患の発症リスクとなることが報告されている。 名古屋大学大学院医学系研究科・黒田啓介先生、貝淵弘三先生（2008）。C57BL/6背景。 DISC1 (delta 2-3), DISC1 KO, Disc1(-) (Acc.No. CDB0583K) DISC1 (delta 2-3), DISC1 KO, Disc1(-) (Acc.No. CDB0583K) C（3〜6か月） <a href='https://brc.riken.jp/mus/pcr03709'>Genotyping protocol -PCR-</a> phage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E.coli neomycin resistance gene, Mouse phosphoglycerate kinase Poly A signal, mouse Disc1 genome DNA In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 20, 4666-4683 (2011).(1) The RECIPIENT shall obtain a prior agreement from Dr. Kouzo Kaibuchi (kaibuchi@med.nagoya-u.ac.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. (CDB0583K) (http://www2.clst.riken.jp/arg/mutant%20mice%20list.html) and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (未定) (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published. Developed by Keisuke Kuroda, Kozo Kaibuchi, Nagoya University, Graduate School of Medicine in 2008. A loxP/PGK-Neo-pA/loxP cassette was transferred into TT2 ES cells to replace most of exon 2 and all of exon 3 of Disc1 gene. The mutant mice were backcrossed to C57BL/6J. RBRC03709 Heterozygote x Wild-type [C57BL/6JJmsSlc] Heterozygote x Wild-type [C57BL/6JJmsSlc] TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] Mouse Models for Human Disease